Cell-cell signaling in angiogenesis and arterial venous hierarchy

The molecular control of angiogenesis, or blood vessel growth, is critical for embryonic development, tissue regeneration, and diseases including cancer and ischemia. The long-term interest of my laboratory is to elucidate the molecular regulators of the cellular processes that occur in endothelial cells lining blood vessel walls. We study these questions through cell-lineage specific, temporally regulatable gene expression and deletion in mice, combined with cellular, molecular, and two-photon in vivo imaging approaches. A key challenge in the study of angiogenesis is the regulation of arterial venous hierarchy. We are currently investigating the function of Notch and ephrin-B2 signaling pathways in arterial venous specification.  This work may unravel signaling cascades regulating crucial vascular pathophysiology and facilitate rational design of therapies to treat cardiovascular diseases and cancer.

Recent Publications

Murphy PA, Lam MT, Wu X, Kim TN, Vartanian SM, Bollen AW, Carlson TR, Wang RA
Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice.
Proceedings of the National Academy of Sciences of the United States of America, Aug-05-2008; 10531: 10901-6
He C, Hu H, Braren R, Fong SY, Trumpp A, Carlson TR, Wang RA
c-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo.
Development (Cambridge, England), Aug-01-2008; 13514: 2467-77
Carlson TR, Hu H, Braren R, Kim YH, Wang RA
Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice.
Development (Cambridge, England), Jun-01-2008; 13512: 2193-202
Dubois NC, Adolphe C, Ehninger A, Wang RA, Robertson EJ, Trumpp A
Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function.
Development (Cambridge, England), Aug-01-2008; 13514: 2455-65.  Epub 2008 Jun 11.
Tward AD, Jones KD, Yant S, Cheung ST, Fan ST, Chen X, Kay MA, Wang R, Bishop JM
Distinct pathways of genomic progression to benign and malignant tumors of the liver.
Proceedings of the National Academy of Sciences of the United States of America, Sep-11-2007; 10437: 14771-6.  Epub 2007 Sep 4.
Braren R, Hu H, Kim YH, Beggs HE, Reichardt LF, Wang R
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation.
The Journal of cell biology, Jan-02-2006; 1721: 151-62.
Yan J, Tang GL, Wang R, Messina LM
Optimization of adenovirus-mediated endothelial nitric oxide synthase delivery in rat hindlimb ischemia.
Gene therapy, Nov-01-2005; 1222: 1640-50.
Proctor JM, Zang K, Wang D, Wang R, Reichardt LF
Vascular development of the brain requires beta8 integrin expression in the neuroepithelium.
The Journal of neuroscience : the official journal of the Society for Neuroscience, Oct-26-2005; 2543: 9940-8.
Carlson TR, Yan Y, Wu X, Lam MT, Tang GL, Beverly LJ, Messina LM, Capobianco AJ, Werb Z, Wang R
Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice.
Proceedings of the National Academy of Sciences of the United States of America, Jul-12-2005; 10228: 9884-9.  Epub 2005 Jun 30.
Carpenter B, Lin Y, Stoll S, Raffai RL, McCuskey R, Wang R
VEGF is crucial for the hepatic vascular development required for lipoprotein uptake.
Development (Cambridge, England), Jul-01-2005; 13214: 3293-303.  Epub 2005 Jun 8.
Tang GL, Chang DS, Sarkar R, Wang R, Messina LM
The effect of gradual or acute arterial occlusion on skeletal muscle blood flow, arteriogenesis, and inflammation in rat hindlimb ischemia.
Journal of vascular surgery, Feb-01-2005; 412: 312-20.
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